Hundreds of thousands of people with alopecia areata may one day benefit from a drug that can cure baldness in months.
A study of the twice-a-day pill found four in 10 patients with the condition were able to regrow nearly a full head of hair within half a year.
The main scientist behind the drug does not expect it to work for the millions of men who lose their hair as they age, however.
Alopecia is the general medical term for hair loss. Alopecia areata — one type of hair loss — is caused by the body attacking its own healthy hair follicles.
Made by the US drugs company Concert Pharmaceuticals, the new therapy works by dampening the immune response, preventing it from going haywire.
There are currently no cures for alopecia areata — although other drug firms are also trialling drugs to help reverse the hair loss. Steroids and other medications can help kick-start hair growth, however.
Around 100,000 people in the UK and 6.8million in the US have the condition. It can rob people of their hair in a few weeks.
Because of the speed of hair loss, the disease can cause low self-esteem, depression and anxiety.
Famous sufferers include actress Jada Pinkett Smith. Her husband Will Smith landed in controversy at this year’s Oscars in March, after he slapped comedian Chris Rock for joking about his wife’s baldness.

Researchers at Yale University, Connecticut, found Concert Pharmaceuticals’ experimental drug CTP-543 helped patients with alopecia areata regrow nearly a full head of hair. Pictured: A patient in previous Phase 2 clinical trials at the start (left) and end (right) of the 24-week study
The latest phase three trial looked at 706 adults with alopecia aged 18 to 65 in the US, Canada and Europe over 24 weeks.
Patients on average had just 16 per cent of their hair at the start of trial, and no more than half a head of hair.
They were spit into three groups, which were given a placebo, an 8mg twice-daily pill or a 12mg twice-daily dose.
Both the 8mg and 12mg groups saw statistically significantly more regrowth than the placebo group, researchers said.
A total of 41.5 per cent given the strongest dose saw more than 80 per cent of their hair regrow by the end of the study.
Among those in the 8mg group, 29.6 per cent experienced the same level of regrowth.
Just 0.8 per cent of the placebo group saw regrowth to more than 80 per cent of the scalp.
Side effects occurred in fewer than 5 per cent of patients, with the most common reactions including headaches, acne and infections.
The drug works by inhibiting a particular enzyme that is activated during an immune response, called JAK1 and JAK2.
These enzymes make up a group called janus kinases, and too much of them can lead to inflammatory immune responses that cause alopecia.
But suppressing them can also lead to weaker immunity across the board, resulting in more infections.
Concert Pharma expects to apply for US Food and Drug Administration (FDA) approval for the drug next year after a second Phase 3 trial, which will repeat the study on 517 participants.
Approval will depend on positive results from the second trial and could take up to 10 months.
Dr James Casella, chief developmental officer at Concert Pharmaceuticals, said: ‘With these compelling Phase 3 data, we believe that CTP-543 has the potential to be a best-in-class treatment for patients with alopecia areata, a disease that has long been ignored.
‘We are extremely grateful to the patients and teams of clinical research professionals who participate in our trials.
‘We’re working to change the treatment landscape and hope that CTP-543 will be one of the first FDA-approved treatment options for this serious disease.’
Alopecia areata does not currently have any cure and doctors cannot predict how much hair someone is likely to lose once small patches begin to fall out.
But there is a 60 to 80 per cent chance hair will regrow naturally in the small areas when it drops out.

Among the most famous people with the disease include actress Jada Pinkett Smith

Her husband Will Smith landed in controversy at this year’s Oscars in March after he slapped comedian Chris Rock for joking about his wife’s baldness
If hair does grow back, it can take months or years and usually starts as sparse white hairs in the bald patches which can eventually thicken and regain their colour.
Regrowth is less likely if all someone’s hair falls out.
Current treatment options include corticosteroid injections, which are powerful anti-inflammatory drugs that can suppress the immune system.
These can work in up to 62 per cent of patients but also increase the risk of cutaneous atrophy — a thinning of the skin — prompting interest in new medications.
Dr Brett King, a dermatologist at Yale University School of Medicine who led the study, said: ‘Today marks an important milestone in advancing new treatments for alopecia areata, and I’m so happy to see such positive results from the first Phase 3 trial with CTP-543.
‘There is a great need for treatments for this challenging disease, and the results from the THRIVE-AA1 trial suggest that CTP-543 may potentially provide an important therapy for treating alopecia areata.’
https://www.dailymail.co.uk/health/article-10852747/Alopecia-drug-regrows-hair-40-patients-condition-suffered-Jada-Pinkett-Smith.html
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